The first shift for new surgical interns Meredith, Cristina, Izzie, George and Alex proves eventful and backbreaking.
Izzie and Cristina are assigned a close-to-brain-dead John Doe who may be a viable candidate for organ donation, and helpful to George's patient, who needs a new liver. Meanwhile, Meredith and Alex butt heads over a patient of their own.
Izzie and George find out about Meredith and Derek, while Cristina makes a discovery of her own. George thinks an anesthesiologist is drinking on the job, and Meredith deals with a young girl who has had illegal surgery.
George discovers he has syphilis, and it soon emerges that the disease is rampant among the hospital staff. Suspicious about a patient's death, Izzie and Cristina perform an unauthorized ...
Meredith, shattered by revelations, is forced to work with Addison, Joe collapses at the bar, Cristina has some pretty shattering news of her own, and Alex starts working on Izzie.
A storm rages, causing power outages and jamming the elevator, trapping George and Alex inside with a vulnerable patient. Meanwhile, Meredith and Derek arrange a religious ritual for a young woman, and Cristina deals with an unusual case.
Friends of Derek and Addison come from New York for a preventative surgery that causes discord among both couples. Meanwhile, George helps a man who has fallen from a roof, and Bailey delivers news to the Chief.
Meredith's one night stand causes complications when he shows up at the hospital with an embarrassing problem. Meanwhile, Burke tries to push Cristina toward the next step, and Alex's problems affect his performance.
Izzie becomes attracted to a male patient with a heart condition, and George treats Bex, an intersex patient. Meanwhile, Meredith's mother receives a visitor, and Derek and Addison's relationship is still rocky.
The nurses are striking, and George refuses to cross the picket line. The interns are surprised by Bailey's seemingly immature replacement, Izzie connects with a pregnant girl, and an elderly woman's plight pushes Meredith to the limit.
Meredith and George face the consequences of their actions, Izzie gets closer to Denny, who has been readmitted, and Addison asks for Bailey's help with an embarrassing ailment.
Cristina babysits for Bailey and does not take to it well at all. Meanwhile, Addison and Derek come to terms with their relationship, George connects with Callie, and Denny continues to come between Alex and Izzie.
Meredith considers going on a date with Finn, and Izzie tries to find out more about George and Callie. Meanwhile, Alex clashes with Addison over a sensitive case, and Burke is nervous about operating on a patient who is one of his heroes.
Burke is admitted as a patient, along with Richard's niece. Izzie and the others fight to keep Denny alive, while Alex tries to secure the donor heart for him.
Richard is determined to discover the guilty party, and punishes the interns by making them arrange a prom for his niece. Meanwhile, Callie presses George about his feelings, and Derek and Meredith have to make a decision about Doc.
Everyone reminisces about the past. Meanwhile, Izzie is emotionally devastated, with the others trying to help her, Adele gives Richard an ultimatum, and George and Derek are put in quarantine when an outbreak of the plague is suspected.
Izzie copes with her grief by baking furiously, and George has to deal with an obstinate patient. Meanwhile, Meredith must choose between Derek and Finn, Addison drowns her sorrows in alcohol, and Cristina meets Burke's difficult mother.
Guilt causes different actions in everyone, the interns are allowed to attend an M&M meeting, and Derek and Addison finalize things.
Derek, George, Alex, Burke, Richard, Joe and Walter go on a camping trip. Meanwhile, Meredith assists Mark with gender reassignment surgery, Izzie avoids discussing her grief, Addison works with Callie, and Cristina feels Bailey's wrath.
George must deal with his family's presence when his father is admitted. Meanwhile, Burke's secret is almost out, Alex tries to get close to Izzie again, and Richard comes to a decision about his marriage.
The interns each react differently to a mass-casualty incident. Meanwhile, George crosses the professional line with Callie, Cristina asks Burke to keep quiet about their engagement, and Richard dons a new hairstyle.
An unconscious Meredith interacts with some ghosts from her past while Richard, Burke and Bailey devise an unusual method of reviving her. A despondent Cristina leaves during her shift, and Derek speaks his mind to Meredith's mother.
Meredith deals with her over protective stepmother, Cristina is caught between Burke and Marlow, and Derek fights to become Chief. Meanwhile, Alex continues the search for Jane Doe's identity, and Izzie's past comes back to haunt her.
The Chairman of Seattle Grace's board of directors is admitted, and the attendings vie for his favor, while the interns study for exams. Izzy and George are reminded of their infidelity, and Burke presses Cristina about wedding plans.
Addison heads for warmer climes to figure things out, Meredith's stepmother visits the clinic, Cristina's perfect wedding is challenged when she and Burke's mothers visit, and Izzie tries to talk to George.
Addison is pulled into the case of a high-risk surrogate mother, Meredith's stepmother develops a complication, Izzie struggles with George's decision, and Ava has surgery which may restore her memory.
The interns face their first year medical exams. With the interns busy, the attendings must do their own legwork, Burke appoints a new best man, Cristina writes her vows, and Callie grows suspicious of George and Izzie.
The wedding day arrives. Richard chooses the new Chief and Chief Resident, the interns receive their exam results, Callie drops a bombshell on George while Izzie pours her heart out to him, and Burke makes an important decision.
The interns, now residents, deal with their own crops of interns. Callie struggles with her new position, and Burke makes a decision.
Lexie persists in trying to get to know Meredith, and Mama Burke descends once more.
Callie hides in her office, frustrating Bailey who's itching to teach someone. Elsewhere, age becomes the theme as Izzie tries to convince 'Really Old Guy' he shouldn't die, Webber and ...
Meredith and her intern lose a patient after they give her the wrong diagnosis, Callie confronts Izzie, and McDreamy bonds with the other Grey.
Meredith feels she's being haunted by her Mother's ashes, and Cristina is denied a surgery for a surprising reason.
A man survives a parachute accident without serious injury, two women refuse treatment because of a wedding contest, and Cristina and Izzie jockey for inclusion in Hahn's surgeries.
Bailey crosses the line when the guy she had a crush on in high school shows up in the ER during an onslaught of high school students involved in a bus crash. The Grey sisters run and hide ...
Tragedy abounds for everyone at Seattle Grace as they all continue in efforts to get the paramedic out of the overturned ambulance, stop the bleeding of a man who won't quit, and a bigot ...
Cristina is still in her slump and turning mean, Izzie finally confronts Ava/Rebecca, and Meredith's anger with her therapist is challenged by a patient with a Cinderella story.
Meredith and Derek find that "happily ever after" isn't as easy as they hoped, Cristina finds interest in a military doctor, and the Chief is surprised to hear that Seattle Grace is no longer ranked as a top-tier teaching hospital.
Calllie worries over her first real date with Erica. Cristina stumbles upon a neglected area of the hospital.
The residents and interns squabbling over procedures upsets Dr. Hunt, Erica discovers what happened to the heart she lost, and Derek asks Sloan to break out the McSteamy to distract Yang.
Derek's mother visits, the death row patient starts angling for death in the hospital, Izzie craves more in her relationships, and Jackson's need for organs becomes critical.
Cristina carries on an intense flirtation with Owen, Derek gets advice from everyone on how to propose, Izzie gets some tests done, and Bailey's promotion may stand in the way of a new career possibility.
Izzie bites off more than she can chew on her first day of chemotherapy, Mark and Derek are forced to work on the same patient, Meredith's plans for a simple wedding take a turn, and Karev ...
Izzie's mother comes to town, a little girl shoots her father triggering a conflict between Meredith and the chief, Thatcher reappears, and Callie gets her first taste of life without her trust fund.
Izzie is torn over whether to have Derek's proposed brain surgery. A soldier on medical leave asks for a radical operation so he can return to active duty. The Chief tries to lure Bailey ...
Thatcher is hospitalized with liver failure, and Meredith fights anger and guilt while deciding her responsibility. Sloan treats an octogenarian who wants an implant. Izzie's interference in Hunt's cancer case may have deadly consequences.
When Isaac, the hospital lab tech, has an inoperable tumor wrapped around his spine, he turns to Dr. Derek Shepherd to do the impossible, and Derek tests the Chief's authority when Richard objects to moving forward with the risky surgery.
A generous donation is offered to Seattle Grace by the parents of Arizona's 10-year-old patient. When his condition worsens, however, she finds herself with a conflict of interest. ...
In his new role as Chief, Derek restores the hospital lecture series, and Richard, Bailey and Callie present to the group pivotal surgical cases from their pasts - Bailey reflects on her ...
Sloan returns to Mark's apartment, just as she's going into labor, and Teddy, Mark and the still-fighting Callie and Arizona are there to help with the birth and to get Mark through his ...
Seattle Grace Hospital is hit with a crisis like no other in its history.
Cristina and Meredith's surgical skills are put to the ultimate test.
The staff tries to deal with physical and emotional trauma in the wake of the deadly rampage.
The residents are pushed to their limits when Owen puts them through a rigorous trauma certification drill; meanwhile, Cristina is also tested when left alone to monitor a very ill lung ...
Derek lands the grant he needs for his clinical trial and all the attendings take him out to Joe's Bar to celebrate, but they get a surprise when they see someone they know already at the ...
Despite Meredith's objections to the idea, a concerned Derek takes Cristina on a fishing trip in order to get away from it all, while Teddy, feeling directionless without Cristina, directs ...
Arizona seeks Mark's advice as she tries to reconcile with Callie, who has big news of her own; Teddy must make a key decision for Henry during his surgery; and on the same day the ...
In a series first, the music that has been at the heart of the show and been beloved by fans comes to life for Grey's Anatomy: The Music Event. A cataclysmic event rattles the doctors of ...
As the official Chief Resident interviews begin, everyone steps up their game in the hopes of impressing Owen. Meanwhile, Meredith anxiously prepares for her first interview with the social worker and Christina fights for a shot in the operating room.
News of Meredith's dishonesty in the clinical trial comes to light, leading to unanticipated consequences for both her and others. Cristina finds herself in a compromising situation, which ...
Meredith faces the repercussions of messing with the medical trial.
The chief makes a decision that shocks everyone at Seattle Grace.
The residents try to impress Jackson's mother, Catherine Avery.
Meredith tries to get Derek interested in a patient's rare brain tumor.
Teddy is called away on another case, as Henry is brought in for surgery.
While Derek prepares to operate on a tumor deemed entirely inoperable, Hunt pressures Meredith to declare a specialty. As Cristina and Teddy try to steal a prized cardio surgery, the doctors celebrate Richard's 10,000th surgery.
Meredith dreams of what her life would have been.
On Valentine's Day Lexie volunteers to watch Zola for Meredith and Derek; Callie plans an evening for Arizona; and Ben shows Bailey how much he cares. Meanwhile, Christina and Owen drift ...
As Adele's condition continues to deteriorate, Richard considers altering their living situation; an explosion at a local coffee shop results in a busy day in the ER for the doctors; Callie...
Derek encourages a hesitant Meredith to work with him again in neurology; Jackson's mother, Catherine Avery, returns to Seattle Grace with a urology fellow and develops an interest in ...
A pet lion on the loose gives the hospital some fierce injuries to deal with. Meanwhile, Cristina continues to ignore Owen, Lexie reconsiders her feelings for Mark, Callie has to face ...
Six hours after their oral boards, the fifth years relive their answers and worry about their chances. Back at the hospital, Bailey has to woo potential candidates for the hospital and Mark...
Months after the plane crash, the doctors at Seattle continue to try and find a new sense of normalcy. With a new set of interns to put through the ringer, the new fellows and attendings ...
Each of the doctors involved in the crash experiences flashbacks that take them back to their time of rescue and explain how they got to where they are now.
The survivors of the crash are presented with a settlement offer, forcing them to choose between putting the incident behind them or investigating the true cause. Meanwhile, Jackson and ...
In an intern-centered episode, Jo and Alex work closely together and Jo discovers she has a certain image. Meanwhile, Meredith's intern is forced to find a donor nerve for Derek's hand and ...
As a jittery Bailey prepares for her wedding, Meredith and Derek disagree on whether or not to go through with the nerve transplant from Lizzie. Then, Cristina learns of the real reason ...
As Bailey puts her wedding on hold to tend to Adele, a biker gang floods the hospital with injuries for all the other doctors to tend to. Meanwhile, Cristina and Owen make a final decision ...
Arizona is grappling with the pain of Phantom Limb when a consultant arrives at the hospital to begin investigations. While Derek embarks on his first major surgery, Meredith faces her biggest fear as she experiences pregnancy mood swings.
Alex and Jackson are pitted against each other to become the next "face" of Seattle Grace while they work on a sex reassignment surgery for a trans-gender teen. Then, April brings in an ...
As the hospital inches closer to finding a buyer, many of the doctors don't like the new changes being made, causing the crash survivors to consider a crazy idea. Meanwhile, April's ...
The transition to new management has the doctors at each others throats. Matters become worse when Owen quits, leaving the OR board in complete disarray.
With the new Grey Sloan Memorial Hospital up and running smoothly, everyone is happy about the new changes. Meredith worries about the health of her baby while Bailey tries to get the board...
With a major storm rolling in, the hospital is chaotic. When Jason comes into the hospital in critical condition, Alex does everything he can to protect Jo. With Meredith's due date just weeks away, Derek urges her to slow down.
As Seattle is plunged into a major storm, Meredith goes into labour. When the hospital loses power, her doctor and all the others are forced to work in the dark. Cristina must perform ...
Following the storm, a mudslide injures first responders and citizens.
Derek and Meredith adjust to life at home with their newborn.
The doctors put together a fundraising gala.
Callie and Derek collaborate on a brain mapping project.
Costumed patients create a challenge for the doctors; Derek and Ben work on a new surgical technique; Richard asks a resident to perform his next surgery, angering Bailey.
Callie's career is on the line when she is being sued for negligence after an operation on a star athlete goes horribly wrong.
April's visiting sisters get on her nerves; when Matthew and Jackson witness an accident, they must work together; Callie and Arizona work on their relationship.
Meredith and Cristina bicker about their careers; Bailey talks to Ben about him moving back to Seattle; Shane puts himself in a risky situation; Derek receives a life-changing phone call.
The doctors face the consequences of the events that took place at April's wedding. Meredith feels betrayed when Derek goes back on a promise, Alex is furious after returning to the ...
Couples panic when the hospital announces a nonfraternization policy; Owen and Emma discuss the future; Meredith and Cristina have some girl time; Richard asks the residents for help with a rare cancer case.
Arizona's bad day escalates when she advises a patient on a potential double amputation; Derek breaks a promise; Stephanie and Jo find an abandoned baby; the nonfraternization rule leads to a suspension.
Arizona realizes that her leg can be repaired, but will she make the sacrifice to get it?
Follows Christina's life as she wonders how her life would take shape based on a single decision.
The doctors of Grey Sloan Memorial Hospital succumb to an infection that spreads like wildfire. Cristina deals with a complex case involving siblings and Alex begins to consider his future in the hospital.
Meredith and Bailey tackle jealousy as Cristina receives an early morning phone call that might change her life; Callie comes to a shocking realization and Alex makes a decision.
Callie and Arizona discuss having another baby, Derek has a hard time juggling work and family, Jackson and April have their first big fight and Christina attends the Harper Avery Award Ceremony. But is she going to win?
Derek's sister Amelia comes for a visit; Alex confronts Arizona and the rest of the hospital about his decision; Dr Webber finds out the truth about Harper Avery award from Catherine.
The doctors work together to operate on two sisters joined at the head; Cristina travels to Zurich where she deals with a blast from her past; Richard voices his concern over the hospital's allegiance with the Harper Avery Foundation.
While Bailey faces dire consequences for her reckless behavior, Cristina interviews candidates for Dr. Russell's replacement. Alex returns with a motive, disappointment hits Callie and Derek brings forth a shocking proposal to Meredith.
Cristina must head to Zurich soon but she is unprepared to leave behind her life in Seattle. Fear runs amok throughout the hospital as an explosion in a shopping mall results in a mass casualty situation.
Callie and Arizona have to make a choice regarding surrogacy while the board has to decide whether to give Cristina's seat on the board to Alex or Bailey. Amelia overhears the truth about Maggie Pierce.
In this Maggie-centric episode, she continues to try to make a positive impression at the hospital but finds herself in extremely unfortunate situations. Meanwhile, Richard continues to ...
Owen introduces Callie to the Veterans Hospital patients in hopes that she will help them with her robotic limb lab, Jo becomes jealous of Alex and Meredith's friendship, and Maggie ...
Secrets from Ellis Grey's past come to light when Meredith watches old videos and reads through her mother's journals. Meanwhile, Maggie rocks the hospital with an unexpected announcement; ...
Callie and Arizona examine their marital problems and what's contributed to them. Meanwhile, Callie devotes herself to the veterans' project; Arizona strives to impress Dr. Herman; and Richard seeks guidance from Bailey.
A woman comes in badly hurt from a car jack and Owen pays some extra attention when she is found to have served in the military. Derek desperately tries to organize a dinner binding ...
Arizona has to take care of one of Herman's patients. Everybody finds out Amelia was a drug addict and Derek lets her down. Jo has her first solo surgery. Maggie is invited to Ellis' house and Arizona decides to move in with Alex.
Pierce and Grey disagree with Derek about the best way to approach a patient's case, which lead the couple to a very big argument. Meanwhile Callie feels responsible for one of her veterans...
Meredith keeps herself busy while Derek prepares for his move; Jackson and April get difficult news; Arizona and Amelia talk about how best to approach Dr. Herman.
April stays positive as tests are run on her baby; Dr. Herman plans a crash course in fetal surgery; Callie and Owen encourage each other to return to the dating scene; Bailey, Meredith and Maggie try to learn more about a patient's tumor.
Meredith tries to find a sitter so she can go visit Derek, Amelia and Stephanie work together on a case.
Maggie gets upset when Meredith dodges her questions about DC; Bailey and Ben become concerned about Ben's brother after he is admitted to the hospital, and Dr. Herman starts to warm up to ...
The hospital doctors become fascinated with Dr. Herman's case when Amelia gives a lecture detailing the intricacies of the surgery. Arizona and Herman continue to bond over the amount of ...
The moment of truth has arrived. Amelia begins the daunting surgery to remove Dr. Herman's tumor. Meanwhile, Arizona takes the lead on a case that means a lot to Dr. Bailey.
An earthquake leaves Maggie trapped in an elevator and threatens Meredith's streak of successful surgeries; Owen gives medical advice over the phone; Ben opens up Jackson.
A man with Alzheimer's crashes into a pregnant woman; Merideth worries about Derek cheating on her and the date of their marriage.
Rattled by recent events, Meredith tries to decide what to do about Derek; Owen is stunned when his mother is admitted to the hospital.
A group of children visit the hospital on a field trip and observe two injured cops rushed into the emergency room. Meanwhile, Stephanie develops a crush on one of the chaperones, and Amelia's forced to confront her feelings about Owen.
Upon realizing that Owen and Amelia have been seeing each other behind her back, Meredith comes down hard on her sister-in-law causing Amelia to rethink things. Meanwhile, Catherine springs...
A small plane crash results in multiple casualties, bringing back terrible memories.
Derek witnesses a horrible car crash and jumps in to save lives.
Jackson struggles to understand April's decision; Ben & Bailey discuss their future; a patient revisits Callie; Amelia tries to deal with her past.
The doctors must set their emotions aside and focus on a catastrophe.
As the doctors continue to tackle an unfathomable crisis, they are reminded of what is important and brought closer together.
In the midst of the sisters' dinner party, Maggie ditches her cooking duties to rush to the hospital. Meanwhile, April steps in to help cook as an attempt to avoid Jackson, and Arizona ...
A high-stakes case is tackled by a team of doctors, and the atmosphere grows tense. Meanwhile, Bailey pressures Ben to evict their roommate; and Arizona enthusiastically reenters the dating scene with a new wingman.
As the rumor mill around the hospital continues to spiral out of control, Grey Sloan Memorial is flooded with injured firefighters from a nearby wildfire. Maggie struggles to keep things ...
Flashbacks reveal the evolution of April and Jackson's relationship, beginning with their initial meeting, and the years-long process of one of Jackson's patients.
A patient from Meredith's first surgery as an intern is re-admitted to the hospital with an aneurysm; Maggie thinks Richard knows about her relationship with Andrew; Arizona considers dating again.
Richard swaps pairings among the residents and attendings, baffling everyone. Meanwhile, Arizona makes a bold decision as she treats a woman who's carrying quadruplets; April faces a tough choice.
Jackson learns about April's pregnancy, while Alex and the team of doctors handles a long triple-organ transplant surgery. Meredith considers dating again, and Andrew insists on not ...
Meredith, Bailey, Jackson, Callie and Jo travel to a military hospital to perform an extraordinary and extremely risky surgery on a veteran with an advanced tumor.
Miranda is faced with the repercussions of Ben's actions; Miranda forms an advisory committee
The doctors work frantically to save a young boy who was accidentally shot. Meanwhile, Arizona is upset when Callie tries to make an important decision about Sophia's future without consulting her.
Stephanie's relationship to Kyle becomes complicated. Meredith encourages Amelia and Owen to take a chance and choose to be a real couple. Arizona and Callie are at odds and put their friends in the middle of an uncomfortable situation.
Callie and Arizona are at odds over Sofia's future, and Stephanie questions the status of her relationship with Kyle. Meanwhile, Alex and April work on a pregnant teen that is readmitted to Grey Sloan Memorial.
Owen and Amelia take their relationship to the next level; Alex has a clearer view of his future with Jo; Callie and Arizona struggle with custody arrangements.
Meredith and Maggie support Amelia on an important day; Jo reveals that she has been keeping secrets from Alex while Arizona and Callie deal with the impact of their custody arrangement. Meanwhile, Ben leaps into action to help a friend.
When one of Grey Sloan's own lands in the hospital, Bailey tries to figure out what happened while the rest of the doctors jump in to help; Meredith juggles huge secrets that affect her ...
Meredith thinks about her loyalties,while Alex deals with the fallout of his actions; Amelia and Owen host a dinner party with surprising guests; Jackson makes a suggestion to help April through her recovery.
A family argues at the hospital following a car crash at a funeral; Arizona is caught between Alex and Andrew; Ben has a new parenting role; Amelia helps Meredith and Maggie work through a problem.
Alex realizes the clinic doesn't make him less of a doctor while Meredith struggles with professionalism with Riggs
Meredith and Bailey are at odds when both of their patients need a liver transplant. Elsewhere, Owen seeks help from the other doctors when he is charged with babysitting baby Harriet for ...
A familiar face returns to Grey Sloan throwing many of the doctors through a loop. With Catherine putting on the pressure, Bailey has to make a decision about Alex while a tough ER case makes Anelia's bad day even worse.